Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.9
USERS' SCORE
Good
Based on 4 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Total Carbohydrate
<1 g
<1%*
Siberian Rhodiola (Rhodiola rosea) root extract
120 mg
†
Rosavins
6 mg
†
Top Medical Research Studies
9.5
We established a mouse model for myocardial infarction (MI) to explore the potential benefits of Salidroside (SAL), a key component of Rhodiola rosea, on heart health after an attack. In our study, we examined whether SAL could lead to better outcomes by reducing mortality and improving cardiac function after MI.
After administering SAL to the mice for 21 days post-surgery, we observed significant improvements compared to those given normal saline. SAL not only reduced the risk of death, but also enhanced heart function by decreasing scar tissue and damage in heart tissues. Furthermore, we found that SAL helped control inflammation and cell death while encouraging new blood vessel growth.
Our findings showed that SAL effectively modulated several biological markers, leading to a healthier response following a heart attack. This suggests that SAL could be a promising treatment for dealing with the aftermath of ischemic heart conditions, making it a noteworthy candidate in the future of cardiovascular therapies.
After administering SAL to the mice for 21 days post-surgery, we observed significant improvements compared to those given normal saline. SAL not only reduced the risk of death, but also enhanced heart function by decreasing scar tissue and damage in heart tissues. Furthermore, we found that SAL helped control inflammation and cell death while encouraging new blood vessel growth.
Our findings showed that SAL effectively modulated several biological markers, leading to a healthier response following a heart attack. This suggests that SAL could be a promising treatment for dealing with the aftermath of ischemic heart conditions, making it a noteworthy candidate in the future of cardiovascular therapies.
Read More
9
We explored the effects of salidroside, a compound derived from the Rhodiola rosea plant, on heart attack recovery in a study involving rats. The researchers focused on how salidroside influences heart cells during oxygen and glucose deprivation, a condition that mimics aspects of a heart attack.
The results were promising. Salidroside helped protect heart cells, improving their survival rates and reducing morphological damage. We observed that this protective effect was linked to a lower rate of apoptosis—or cell death—among the heart cells, as indicated by fewer reactive oxygen species (ROS) being produced. Moreover, salidroside led to an increased ratio of beneficial proteins that help prevent cell death, while also maintaining the proper function of mitochondria, which are the energy centers of cells.
Additionally, when salidroside was administered to rats with induced heart attacks, it was effective in reducing myocardial apoptosis and enhancing certain biochemical pathways that promote cell survival. Overall, these findings highlight salidroside's potential as a therapeutic agent in preventing and treating heart-related issues, making it a promising candidate for future research.
The results were promising. Salidroside helped protect heart cells, improving their survival rates and reducing morphological damage. We observed that this protective effect was linked to a lower rate of apoptosis—or cell death—among the heart cells, as indicated by fewer reactive oxygen species (ROS) being produced. Moreover, salidroside led to an increased ratio of beneficial proteins that help prevent cell death, while also maintaining the proper function of mitochondria, which are the energy centers of cells.
Additionally, when salidroside was administered to rats with induced heart attacks, it was effective in reducing myocardial apoptosis and enhancing certain biochemical pathways that promote cell survival. Overall, these findings highlight salidroside's potential as a therapeutic agent in preventing and treating heart-related issues, making it a promising candidate for future research.
Read More
9
We explored the effects of salidroside, a natural extract from Rhodiola rosea, on heart damage caused by a lack of blood flow, known as ischemia-reperfusion (I/R) injury, in rats. The study involved inducing this injury in Wistar rat hearts and then treating them with salidroside.
Our findings showed that salidroside significantly improved cardiac function. It reduced the size of heart damage, and lowered levels of important cardiac markers like CK-MB and LDH, indicating better heart health. Additionally, salidroside showed an ability to manage oxidative stress in the heart.
Importantly, we also observed that salidroside inhibited processes of cell death and self-digestion, known as apoptosis and autophagy respectively. This effect could be reversed by introducing an agent that promotes autophagy, suggesting that salidroside controls these processes effectively. Lastly, salidroside's benefits appear to be linked to increasing levels of a specific circular RNA, hsa_circ_0000064, which plays a role in cell regulation.
All in all, our study indicates that salidroside may offer a protective effect against heart damage during I/R injury, potentially through its influence on certain biological processes and molecules related to cellular health.
Our findings showed that salidroside significantly improved cardiac function. It reduced the size of heart damage, and lowered levels of important cardiac markers like CK-MB and LDH, indicating better heart health. Additionally, salidroside showed an ability to manage oxidative stress in the heart.
Importantly, we also observed that salidroside inhibited processes of cell death and self-digestion, known as apoptosis and autophagy respectively. This effect could be reversed by introducing an agent that promotes autophagy, suggesting that salidroside controls these processes effectively. Lastly, salidroside's benefits appear to be linked to increasing levels of a specific circular RNA, hsa_circ_0000064, which plays a role in cell regulation.
All in all, our study indicates that salidroside may offer a protective effect against heart damage during I/R injury, potentially through its influence on certain biological processes and molecules related to cellular health.
Read More
Most Useful Reviews
9
Immediate effects
When my heart feels weak, consuming Rhodiola rosea is immediately effective.
Read More
6
Mental health boost
5 people found this helpful
Fabulous for anyone who suffers from mood swings, Rhodiola rosea is renowned for aiding the body’s adaptation to stress, functioning as an adaptogen. A report from the Journal of Alternative Medicine, based on multiple small studies, indicates that extracts of Rhodiola rosea benefit mental health and heart function. It is described as a versatile herb that can enhance resistance to stress, with potential to lower stress hormones and alleviate heart problems associated with stress.
Read More
7.5
Focus and endurance
1 people found this helpful
Worth the premium price, I find Rhodiola rosea to be the most potent adaptogen. It enhances mental focus and perseverance while also helping to maintain a lower heart rate during cardio sessions.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.9
- All Researches
9.5
We established a mouse model for myocardial infarction (MI) to explore the potential benefits of Salidroside (SAL), a key component of Rhodiola rosea, on heart health after an attack. In our study, we examined whether SAL could lead to better outcomes by reducing mortality and improving cardiac function after MI.
After administering SAL to the mice for 21 days post-surgery, we observed significant improvements compared to those given normal saline. SAL not only reduced the risk of death, but also enhanced heart function by decreasing scar tissue and damage in heart tissues. Furthermore, we found that SAL helped control inflammation and cell death while encouraging new blood vessel growth.
Our findings showed that SAL effectively modulated several biological markers, leading to a healthier response following a heart attack. This suggests that SAL could be a promising treatment for dealing with the aftermath of ischemic heart conditions, making it a noteworthy candidate in the future of cardiovascular therapies.
After administering SAL to the mice for 21 days post-surgery, we observed significant improvements compared to those given normal saline. SAL not only reduced the risk of death, but also enhanced heart function by decreasing scar tissue and damage in heart tissues. Furthermore, we found that SAL helped control inflammation and cell death while encouraging new blood vessel growth.
Our findings showed that SAL effectively modulated several biological markers, leading to a healthier response following a heart attack. This suggests that SAL could be a promising treatment for dealing with the aftermath of ischemic heart conditions, making it a noteworthy candidate in the future of cardiovascular therapies.
Read More
9
We explored the effects of salidroside, a natural extract from Rhodiola rosea, on heart damage caused by a lack of blood flow, known as ischemia-reperfusion (I/R) injury, in rats. The study involved inducing this injury in Wistar rat hearts and then treating them with salidroside.
Our findings showed that salidroside significantly improved cardiac function. It reduced the size of heart damage, and lowered levels of important cardiac markers like CK-MB and LDH, indicating better heart health. Additionally, salidroside showed an ability to manage oxidative stress in the heart.
Importantly, we also observed that salidroside inhibited processes of cell death and self-digestion, known as apoptosis and autophagy respectively. This effect could be reversed by introducing an agent that promotes autophagy, suggesting that salidroside controls these processes effectively. Lastly, salidroside's benefits appear to be linked to increasing levels of a specific circular RNA, hsa_circ_0000064, which plays a role in cell regulation.
All in all, our study indicates that salidroside may offer a protective effect against heart damage during I/R injury, potentially through its influence on certain biological processes and molecules related to cellular health.
Our findings showed that salidroside significantly improved cardiac function. It reduced the size of heart damage, and lowered levels of important cardiac markers like CK-MB and LDH, indicating better heart health. Additionally, salidroside showed an ability to manage oxidative stress in the heart.
Importantly, we also observed that salidroside inhibited processes of cell death and self-digestion, known as apoptosis and autophagy respectively. This effect could be reversed by introducing an agent that promotes autophagy, suggesting that salidroside controls these processes effectively. Lastly, salidroside's benefits appear to be linked to increasing levels of a specific circular RNA, hsa_circ_0000064, which plays a role in cell regulation.
All in all, our study indicates that salidroside may offer a protective effect against heart damage during I/R injury, potentially through its influence on certain biological processes and molecules related to cellular health.
Read More
9
We explored the effects of salidroside, a compound derived from the Rhodiola rosea plant, on heart attack recovery in a study involving rats. The researchers focused on how salidroside influences heart cells during oxygen and glucose deprivation, a condition that mimics aspects of a heart attack.
The results were promising. Salidroside helped protect heart cells, improving their survival rates and reducing morphological damage. We observed that this protective effect was linked to a lower rate of apoptosis—or cell death—among the heart cells, as indicated by fewer reactive oxygen species (ROS) being produced. Moreover, salidroside led to an increased ratio of beneficial proteins that help prevent cell death, while also maintaining the proper function of mitochondria, which are the energy centers of cells.
Additionally, when salidroside was administered to rats with induced heart attacks, it was effective in reducing myocardial apoptosis and enhancing certain biochemical pathways that promote cell survival. Overall, these findings highlight salidroside's potential as a therapeutic agent in preventing and treating heart-related issues, making it a promising candidate for future research.
The results were promising. Salidroside helped protect heart cells, improving their survival rates and reducing morphological damage. We observed that this protective effect was linked to a lower rate of apoptosis—or cell death—among the heart cells, as indicated by fewer reactive oxygen species (ROS) being produced. Moreover, salidroside led to an increased ratio of beneficial proteins that help prevent cell death, while also maintaining the proper function of mitochondria, which are the energy centers of cells.
Additionally, when salidroside was administered to rats with induced heart attacks, it was effective in reducing myocardial apoptosis and enhancing certain biochemical pathways that promote cell survival. Overall, these findings highlight salidroside's potential as a therapeutic agent in preventing and treating heart-related issues, making it a promising candidate for future research.
Read More
4
We explored the potential benefits of rhodiola treatment in protecting the heart during a heart attack. The study involved administering extracts of Panax ginseng and Rhodiola rosea to artificially ventilated, chloralose-anaesthetized rats over five days. The results showed a notable decrease in the size of heart damage during a 45-minute ischemic event, followed by a two-hour reperfusion period.
However, we also found that a single dose of rhodiola given just 24 hours prior to ischemia did not alter the damage levels, suggesting that timing and duration of treatment are critical to its effectiveness. Interestingly, while rhodiola did not mimic ischemic preconditioning—a phenomenon where the heart becomes resistant to damage from lack of blood flow—its regular intake seemed to offer some cardioprotective effects.
Additionally, pretreatment with rhodiola reduced the incidence of dangerous arrhythmias during the ischemic phase, which points to its potential for additional heart rhythm stabilization. Despite these benefits, it's essential to note that extracts of rhodiola may not be the singular solution for heart attack scenarios, particularly when studied alongside other treatments.
However, we also found that a single dose of rhodiola given just 24 hours prior to ischemia did not alter the damage levels, suggesting that timing and duration of treatment are critical to its effectiveness. Interestingly, while rhodiola did not mimic ischemic preconditioning—a phenomenon where the heart becomes resistant to damage from lack of blood flow—its regular intake seemed to offer some cardioprotective effects.
Additionally, pretreatment with rhodiola reduced the incidence of dangerous arrhythmias during the ischemic phase, which points to its potential for additional heart rhythm stabilization. Despite these benefits, it's essential to note that extracts of rhodiola may not be the singular solution for heart attack scenarios, particularly when studied alongside other treatments.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Immediate effects
When my heart feels weak, consuming Rhodiola rosea is immediately effective.
Read More
6
Mental health boost
5 people found this helpful
Fabulous for anyone who suffers from mood swings, Rhodiola rosea is renowned for aiding the body’s adaptation to stress, functioning as an adaptogen. A report from the Journal of Alternative Medicine, based on multiple small studies, indicates that extracts of Rhodiola rosea benefit mental health and heart function. It is described as a versatile herb that can enhance resistance to stress, with potential to lower stress hormones and alleviate heart problems associated with stress.
Read More
7.5
Focus and endurance
1 people found this helpful
Worth the premium price, I find Rhodiola rosea to be the most potent adaptogen. It enhances mental focus and perseverance while also helping to maintain a lower heart rate during cardio sessions.
Read More
7.5
Strength restoration
Rhodiola rosea can alleviate heart weakness and reduce edema effectively.
Read More
Frequently Asked Questions
9
Immediate effects
When my heart feels weak, consuming Rhodiola rosea is immediately effective.
7.5
Focus and endurance
1 people found this helpful
Worth the premium price, I find Rhodiola rosea to be the most potent adaptogen. It enhances mental focus and perseverance while also helping to maintain a lower heart rate during cardio sessions.
6
Mental health boost
5 people found this helpful
Fabulous for anyone who suffers from mood swings, Rhodiola rosea is renowned for aiding the body’s adaptation to stress, functioning as an adaptogen. A report from the Journal of Alternative Medicine, based on multiple small studies, indicates that extracts of Rhodiola rosea benefit mental health and heart function. It is described as a versatile herb that can enhance resistance to stress, with potential to lower stress hormones and alleviate heart problems associated with stress.
7.5
Strength restoration
Rhodiola rosea can alleviate heart weakness and reduce edema effectively.
9
We explored the effects of salidroside, a natural extract from Rhodiola rosea, on heart damage caused by a lack of blood flow, known as ischemia-reperfusion (I/R) injury, in rats. The study involved inducing this injury in Wistar rat hearts and then treating them with salidroside.
Our findings showed that salidroside significantly improved cardiac function. It reduced the size of heart damage, and lowered levels of important cardiac markers like CK-MB and LDH, indicating better heart health. Additionally, salidroside showed an ability to manage oxidative stress in the heart.
Importantly, we also observed that salidroside inhibited processes of cell death and self-digestion, known as apoptosis and autophagy respectively. This effect could be reversed by introducing an agent that promotes autophagy, suggesting that salidroside controls these processes effectively. Lastly, salidroside's benefits appear to be linked to increasing levels of a specific circular RNA, hsa_circ_0000064, which plays a role in cell regulation.
All in all, our study indicates that salidroside may offer a protective effect against heart damage during I/R injury, potentially through its influence on certain biological processes and molecules related to cellular health.
Our findings showed that salidroside significantly improved cardiac function. It reduced the size of heart damage, and lowered levels of important cardiac markers like CK-MB and LDH, indicating better heart health. Additionally, salidroside showed an ability to manage oxidative stress in the heart.
Importantly, we also observed that salidroside inhibited processes of cell death and self-digestion, known as apoptosis and autophagy respectively. This effect could be reversed by introducing an agent that promotes autophagy, suggesting that salidroside controls these processes effectively. Lastly, salidroside's benefits appear to be linked to increasing levels of a specific circular RNA, hsa_circ_0000064, which plays a role in cell regulation.
All in all, our study indicates that salidroside may offer a protective effect against heart damage during I/R injury, potentially through its influence on certain biological processes and molecules related to cellular health.
9.5
We established a mouse model for myocardial infarction (MI) to explore the potential benefits of Salidroside (SAL), a key component of Rhodiola rosea, on heart health after an attack. In our study, we examined whether SAL could lead to better outcomes by reducing mortality and improving cardiac function after MI.
After administering SAL to the mice for 21 days post-surgery, we observed significant improvements compared to those given normal saline. SAL not only reduced the risk of death, but also enhanced heart function by decreasing scar tissue and damage in heart tissues. Furthermore, we found that SAL helped control inflammation and cell death while encouraging new blood vessel growth.
Our findings showed that SAL effectively modulated several biological markers, leading to a healthier response following a heart attack. This suggests that SAL could be a promising treatment for dealing with the aftermath of ischemic heart conditions, making it a noteworthy candidate in the future of cardiovascular therapies.
After administering SAL to the mice for 21 days post-surgery, we observed significant improvements compared to those given normal saline. SAL not only reduced the risk of death, but also enhanced heart function by decreasing scar tissue and damage in heart tissues. Furthermore, we found that SAL helped control inflammation and cell death while encouraging new blood vessel growth.
Our findings showed that SAL effectively modulated several biological markers, leading to a healthier response following a heart attack. This suggests that SAL could be a promising treatment for dealing with the aftermath of ischemic heart conditions, making it a noteworthy candidate in the future of cardiovascular therapies.
4
We explored the potential benefits of rhodiola treatment in protecting the heart during a heart attack. The study involved administering extracts of Panax ginseng and Rhodiola rosea to artificially ventilated, chloralose-anaesthetized rats over five days. The results showed a notable decrease in the size of heart damage during a 45-minute ischemic event, followed by a two-hour reperfusion period.
However, we also found that a single dose of rhodiola given just 24 hours prior to ischemia did not alter the damage levels, suggesting that timing and duration of treatment are critical to its effectiveness. Interestingly, while rhodiola did not mimic ischemic preconditioning—a phenomenon where the heart becomes resistant to damage from lack of blood flow—its regular intake seemed to offer some cardioprotective effects.
Additionally, pretreatment with rhodiola reduced the incidence of dangerous arrhythmias during the ischemic phase, which points to its potential for additional heart rhythm stabilization. Despite these benefits, it's essential to note that extracts of rhodiola may not be the singular solution for heart attack scenarios, particularly when studied alongside other treatments.
However, we also found that a single dose of rhodiola given just 24 hours prior to ischemia did not alter the damage levels, suggesting that timing and duration of treatment are critical to its effectiveness. Interestingly, while rhodiola did not mimic ischemic preconditioning—a phenomenon where the heart becomes resistant to damage from lack of blood flow—its regular intake seemed to offer some cardioprotective effects.
Additionally, pretreatment with rhodiola reduced the incidence of dangerous arrhythmias during the ischemic phase, which points to its potential for additional heart rhythm stabilization. Despite these benefits, it's essential to note that extracts of rhodiola may not be the singular solution for heart attack scenarios, particularly when studied alongside other treatments.
References
- Jin P, Li LH, Shi Y, Hu NB. Salidroside inhibits apoptosis and autophagy of cardiomyocyte by regulation of circular RNA hsa_circ_0000064 in cardiac ischemia-reperfusion injury. Gene. 2021;767:145075. doi:10.1016/j.gene.2020.145075
- Chen P, Liu J, Ruan H, Zhang M, Wu P, et al. Protective effects of Salidroside on cardiac function in mice with myocardial infarction. Sci Rep. 2019;9:18127. doi:10.1038/s41598-019-54713-x
- Zhong H, Xin H, Wu LX, Zhu YZ. Salidroside attenuates apoptosis in ischemic cardiomyocytes: a mechanism through a mitochondria-dependent pathway. J Pharmacol Sci. 2010;114:399.
- Arbuzov AG, Maslov LN, Burkova VN, Krylatov AV, Konkovskaia IuN, et al. [Phytoadaptogens-induced phenomenon similar to ischemic preconditioning]. Ross Fiziol Zh Im I M Sechenova. 2009;95:398.
